USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PSA1_HUMAN USC-OGP 2-DE database:  PSA1_HUMAN PSA1_HUMAN General information about the entry View entry in simple text format Entry name PSA1_HUMAN Primary accession number P25786 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit alpha type-1; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=30 kDa prosomal protein; Short=PROS-30; AltName: Full=Macropain subunit C2; AltName: Full=Multicatalytic endopeptidase complex subunit C2; AltName: Full=Proteasome component C2; AltName: Full=Proteasome nu chain;. Gene name Name=PSMA1 Synonyms=HC2, NU, PROS30, PSC2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0479: pI=5.95; Mw=30817 SPOT OGP-0482: pI=6.09; Mw=30592 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0788: pI=5.91; Mw=29973 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0993: pI=6.10; Mw=28052 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1257: pI=6.46; Mw=30456 SPOT OGP-1263: pI=6.56; Mw=29778 Cross-references UniProtKB/Swiss-Prot P25786; PSA1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSA1_HUMAN Primary accession number P25786 Secondary accession number(s) A8K400 Q53YE8 Q9BRV9 Sequence was last modified on  May 1, 1992 (version 1) Annotations were last modified on  March 15, 2017 (version 197) Name and origin of the protein Description RecName: Full=Proteasome subunit alpha type-1; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=30 kDa prosomal protein; Short=PROS-30; AltName: Full=Macropain subunit C2; AltName: Full=Multicatalytic endopeptidase complex subunit C2; AltName: Full=Proteasome component C2; AltName: Full=Proteasome nu chain; Gene name Name=PSMA1 Synonyms=HC2, NU, PROS30, PSC2 Encoded on Name=PSMA1; Synonyms=HC2, NU, PROS30, PSC2 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Immunity; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X61969; CAA43961.1; -; mRNA EMBL D00759; BAA00656.1; -; mRNA EMBL M64992; AAA92734.1; -; mRNA EMBL BT006647; AAP35293.1; -; mRNA EMBL AK290765; BAF83454.1; -; mRNA EMBL CH471064; EAW68479.1; -; Genomic_DNA EMBL BC002577; AAH02577.1; -; mRNA EMBL BC005932; AAH05932.1; -; mRNA EMBL BC008472; AAH08472.1; -; mRNA EMBL BC009576; AAH09576.1; -; mRNA EMBL BC015105; AAH15105.1; -; mRNA EMBL BC015356; AAH15356.1; -; mRNA EMBL BC022372; AAH22372.1; -; mRNA CCDS CCDS31431.1; -. [P25786-2]; . CCDS CCDS7816.1; -. [P25786-1]; . PIR JC1445; JC1445; . RefSeq NP_002777.1; NM_002786.3. [P25786-1]; . RefSeq NP_683877.1; NM_148976.2. [P25786-2]; . UniGene Hs.102798; -; . PDB 4R3O; X-ray; 2.60 A; F/T=4-241 PDB 4R67; X-ray; 2.89 A; F/T/h/v=4-241 PDB 5A0Q; EM; 3.50 A; F/T=1-263 PDB 5GJQ; EM; 4.50 A; G/m=1-263 PDB 5GJR; EM; 3.50 A; G/m=1-263 PDB 5L4G; EM; 4.02 A; F/S=1-263 PDB 5LE5; X-ray; 1.80 A; E/S=1-263 PDB 5LEX; X-ray; 2.20 A; E/S=1-263 PDB 5LEY; X-ray; 1.90 A; E/S=1-263 PDB 5LEZ; X-ray; 2.19 A; E/S=1-263 PDB 5LF0; X-ray; 2.41 A; E/S=1-263 PDB 5LF1; X-ray; 2.00 A; E/S=1-263 PDB 5LF3; X-ray; 2.10 A; E/S=1-263 PDB 5LF4; X-ray; 1.99 A; E/S=1-263 PDB 5LF6; X-ray; 2.07 A; E/S=1-263 PDB 5LF7; X-ray; 2.00 A; E/S=1-263 PDB 5T0C; EM; 3.80 A; AL/BL=2-263 PDB 5T0G; EM; 4.40 A; L=2-263 PDB 5T0H; EM; 6.80 A; L=2-263 PDB 5T0I; EM; 8.00 A; L=2-263 PDB 5T0J; EM; 8.00 A; L=2-263 PDBsum 4R3O; -; . PDBsum 4R67; -; . PDBsum 5A0Q; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5LE5; -; . PDBsum 5LEX; -; . PDBsum 5LEY; -; . PDBsum 5LEZ; -; . PDBsum 5LF0; -; . PDBsum 5LF1; -; . PDBsum 5LF3; -; . PDBsum 5LF4; -; . PDBsum 5LF6; -; . PDBsum 5LF7; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P25786; -; . SMR P25786; -; . BioGrid 111655; 194; . DIP DIP-29369N; -; . IntAct P25786; 166; . MINT MINT-1155600; -; . STRING 9606.ENSP00000414359; -; . BindingDB P25786; -; . ChEMBL CHEMBL2364701; -; . MEROPS T01.976; -; . iPTMnet P25786; -; . PhosphoSitePlus P25786; -; . SwissPalm P25786; -; . BioMuta PSMA1; -; . DMDM 130848; -; . OGP P25786; -; . REPRODUCTION-2DPAGE IPI00016832; -; . EPD P25786; -; . MaxQB P25786; -; . PaxDb P25786; -; . PeptideAtlas P25786; -; . PRIDE P25786; -; . TopDownProteomics P25786-1; -. [P25786-1]; . DNASU 5682; -; . Ensembl ENST00000396394; ENSP00000379676; ENSG00000129084. [P25786-1]; . Ensembl ENST00000418988; ENSP00000414359; ENSG00000129084. [P25786-2]; . GeneID 5682; -; . KEGG hsa:5682; -; . UCSC uc001mlk.4; human. [P25786-1]; . CTD 5682; -; . DisGeNET 5682; -; . GeneCards PSMA1; -; . HGNC HGNC:9530; PSMA1; . HPA CAB033765; -; . HPA HPA037646; -; . HPA HPA043891; -; . MalaCards PSMA1; -; . MIM 602854; gene; . neXtProt NX_P25786; -; . OpenTargets ENSG00000129084; -; . PharmGKB PA33875; -; . eggNOG KOG0863; Eukaryota; . eggNOG COG0638; LUCA; . GeneTree ENSGT00550000074855; -; . HOGENOM HOG000091080; -; . HOVERGEN HBG105373; -; . InParanoid P25786; -; . KO K02725; -; . OMA CPSANYY; -; . OrthoDB EOG091G0DNK; -; . PhylomeDB P25786; -; . TreeFam TF106206; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMA1; human; . GeneWiki Proteasome_(prosome; _macropain)_subunit; _alpha_1; - GenomeRNAi 5682; -; . PRO PR:P25786; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000129084; -; . CleanEx HS_PSMA1; -; . ExpressionAtlas P25786; baseline and differential; . Genevisible P25786; HS; . GO GO:0005813; C:centrosome; IDA:HPA; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005844; C:polysome; TAS:ProtInc; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:0019773; C:proteasome core complex; alpha-subunit complex; IEA:InterPro GO GO:0003723; F:RNA binding; TAS:ProtInc; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR000426; Proteasome_asu_N; . InterPro IPR023332; Proteasome_suA-type; . InterPro IPR001353; Proteasome_sua/b; . Pfam PF00227; Proteasome; 1; . Pfam PF10584; Proteasome_A_N; 1; . SMART SM00948; Proteasome_A_N; 1; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00388; PROTEASOME_ALPHA_1; 1; . PROSITE PS51475; PROTEASOME_ALPHA_2; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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